丁侃，1996 年 7 月在中国药科大学获生来自药学专业硕士学位， 1999 年 8 月在中国科学院上海药物研究所获有机化学博士学位。 1999 年 9 月至 2005 年 11 月年360百科分别在瑞典隆德大学 (Lund University) ，美国加州大学、欧文分校 (University of California, Irvine) ，美国哈佛大学医学院、麻省总院 (Harvard Medica双践大传克比房转l School/MGH, Harvard University) 进行博士后训练， 2005 年 12月，被中国科学院以"百人计划"形式引进回国，始任中国科学院上海药物研究所研究员，博士生导师。

• 中文名称 丁侃
• 国籍 中国
• 民族 汉族
• 职业 中国科学院上海药物研究所研究员，博士生导师
• 毕业院校 中国药科大学获生药学专业

人物宣经历

教育经历

　　1993.09.01-1996.07.01，中国药科大学，生药学专业，理学硕士。师从李萍教授和中药学家徐国钧院士。

　　1996.09.01-1999.07.01，中国科学院上海药物研究所，有机化学专业(中药多糖化学研究方向)，理学博士。师从多糖化学专家方积年研究员。

工作经历

　　1飞父986.08.01-1993.08.31，江苏药科学校(现为中国来自药科大学高等职业技术学院)，教师

　　1999.09.01-2001.11.01，瑞360百科典隆德大学(Lun武准保d University)，细胞与分子生物学系，博士后，细胞与分子生物学领域(糖生物学研粮某江唱究方向)。师从糖生物学家Lars-Åke Fransson教授从事细胞膜蛋白聚糖结构与功能研究。

　　2001.12.01-2003.12.01，美国加州大学欧文分校，发育与细胞生物学系，博士后(Research Fellow, associate)，细胞与分子生物研究领域(糖生物学研究方向)。师从糖生物学家Arthur D. Lander教授从事蛋白聚糖的功能机制研究。

　　2004.01.01-2005.11.01，美国哈佛大学医学院，麻省总院神经科学研究讨始多路植副知中心，博士后(Research Fellow)，细胞与分子显生物学研究领域(糖生物学与脑中风研究方向)。师从脑神经学家Michael A. 南友Moskowitz教授和Christian Wae父杆态ber博士研究第二信使分子和蛋白聚糖在脑中风中的功能机制值吗。

　　2006.01.01-至今，中国科学院上海药物研究所，研究员，博士生导刑散规师，课题组长，"百人计划"择优获得者，国家杰出青年基金获得者。从事细胞膜蛋白聚糖及其相关酶和miRNA的功能机制研究。否药什游袁示双绝系停同时进行中药多糖的作用机制，多糖靶分子发现，活性机制，构效关系及中药通伤多糖药物发现的研究。

社会职务

　　现任美国功能性糖组学国际科学研究计划参与研究员，国家食品药品监督管理局药品审评中心评审专家，中国生物化学与分效子生物学会糖复合物专业委员会常委委员，国际期刊"Open Glyco训science"编委。

研究方向

　　现主要从事肿瘤效容序中细胞膜蛋白聚糖结构与功能机制研究，多糖和寡糖的生物活性，构效关系，和作用机制研究，并值批位八在此基础上从事基于糖的药物新息放办升谓角传靶标和新药发现研究。

主要贡献

科资宪够香督离变跑位兰研成果

　　建立了糖类药物研发平台，已为国内外北大学，科研院所和企来自业服务提供多糖，寡糖分离选林再办物门案纯化，结构鉴定，纯度分析，工艺因肉三声身什减防天规干改造，质量控制，功能机制研究等多项服务。

　　建立了两个新药筛选平台:一个是靶向转录因子Id360百科1的抗肿瘤药物筛选平台，一个是抗炎药物和免疫系统药物价笑许养族鸡米声肥田筛选平台。

　　从300百多种中草药中提取、纯化700余种多糖组分及化合物，鉴定了部分结构。

　　发现25个NF-k图将热发appaB抑制剂，70个 N丰什F-kappaB激活剂，22个抗癌生物活性化合物。其中5个可以成为候选药。

　　申请4项专利(一项国际专利)，获准一项专利，研究成果主要发表在Journal of Cell Biology，Journal of Biological Chemistry，Cancer Letters, Carbohydrate Research, Carbohydrate Polymers，Journal of Nat械国制丰套善英饭办本氢ural Products等期刊上，共33篇。

型众银杆丝车海儿项粒代表论著

　　1.Li J, Fang J, Qin Y, Liao W, Liu H, Zhou Y*, Ding K*. Glce regulates PC12 cell neuritogenesis i宣又nduced by 角脸范却除据nerve growth fact满假席or through activating Smad/Id3 signaling. Biochem J. 2014, 459(2): 405-416 (*Corresponding author).

　　2.Xiao F尽给王远自案, Qiu H, Cui H, Ni X, Li J, Liao W, Lu N, Ding K*. MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xen弦ografts by di深srupting angiogenesis via targeting BMPR1A and bl资就烟判图至弦费菜ocking BMP/Smad兰/Id1 signaling. Oncogene, 2014, Ju阻总巴改象确杀利连九确n 2;0. doi: 10.1038/onc.2014.134.

　　3.Liu H, Zhou L, Shi S, Wang Y, Ni X, Xiao F, Wang S, Li P* Ding K*. Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling. Glycobiology, 2014 May 5. pii: cwu038. [Epub ahead of print].

　　4.Cong Q, Shang M, Dong Q*, Liao W, Xiao F, Ding K*. Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative. Carbohydr Res. 2014; 393C:43-50.

　　5.Cong Q, Xiao F, Liao W, Dong Q*, Ding K*. Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative. Int J Biol Macromol. 2014, May 28. pii: S0141-8130(14)00352-3. doi: 10.1016/j.ijbiomac.2014.05.056.

　　6.Wang P, Liao W, Fang J, Liu Q, Yao J, Hu M, Ding K*. A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42. Carbohydr. Polym. 2014, 110C:142-147.

　　7.Wang Y, Shen X, Liao W, Fang J, Chen X, Dong Q, Ding K*. A heteropolysaccharide, l-fuco-d-manno-1,6-d-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative. Carbohydr Polym. 2014, 101: 631-41.

　　8.Shi L*, Dong Q, Ding K*. Structure elucidation and immunomodulatory activity in vitro of a xylan from roots of Cudrania tricuspidata. 2014，Food Chem. 152:291-296.

　　9.Peipei Wang, Kan Ding*. Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease. Protein Pept. Lett. 2014, (Reference #: K_DING_PPL_ Manuscript_20130610, in press)

　　10.Wang Y, Fang J, Ni X, Li J, Liu Q, Dong Q, Duan J*, Ding K*. Inducement of Cytokine Release by GFPBW2, a Novel Polysaccharide from Fruit Bodies of Grifola frondosa, through Dectin-1 in Macrophages. J Agric Food Chem. 2013, 61(47):11400-9..

　　11.Xiao F, Qiu H, Zhou L, Shen X, Yang L, Ding K*. WSS25 inhibits Dicer, downregulating microRNA-210 which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology. 2013, 23(5):524-35.

　　12.Zhang, X Liao, W Cong, Q Dong, Q* Ding, K*. Isolation and structural characterization of the polysaccharides of cortex mori radices. Acta Chimica Sinica, 2013, DOI:10.6023/A13010109

　　13.Feng C, Li J, Ruan J, Ding K*. MicroRNA-125a inhibits cell growth by targeting glypican-4. Glycoconj J. 2012, 29(7):503-11.

　　14.Shang M, Zhang X, Dong Q,* Yao J, Liu Q, Ding K* Isolation and structural characterization of the water-extractable polysaccharides from Cassia obtusifolia seeds. Carbohydr. Polym, 2012, 90(2):827-32.

　　15.Liu Y, Fang J, Cai H, Xiao F, Ding K*, Hu Y*. Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors. Bioorg Med Chem. 2012, 20(18):5473-82.

　　16.Chen X, Xiao F, Wang Y, Fang J, Ding K* Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects. Glycoconj J. 2012, 29(5-6):389-98.

　　17.Fang J, Wang Y, Lv X, Shen X, Ni X, Ding K*. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J. 2012, 29(5-6): 365-77.

　　18.Fang JP, Liu Y, Li J, Liao WF, Hu YH*, Ding K*.A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis. Acta Pharmacol Sin. 2012, 33(9):1204-16.

　　19.Lv XF, Chen SH, Li J, Fang JP, Guo YW*, Ding K*. Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro. Acta Pharmacol Sin. 2012, 33(10):1293-300.

　　20.Dong Q, Wang Y, Shi L, Yao J, Li J, Ma F, Ding K *. A novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidum. Carbohydr Res. 2012, 353:100-5.

　　21.Cui H, Shao C, Liu Q, Yu W, Fang J, Yu W, Ali A, Ding K*. Heparanase enhances nerve growth factor induced PC12 cell neuritogenesis via the p38 MAPK pathway. Biochem J. 2011, 440(2)273-282.

　　22.Shen X, Fang J, Lv X, Pei Z, Wang Y, Jiang S, Ding K*. Heparin impairs angiogenesis through inhibition of MicroRNA-10b. J Biol Chem. 2011, 286(30):26616-272.

　　23.Chen X, Cao D, Zhou L, Jin H, Dong Q, Yao J, Ding K*. Structure of a polysaccharide from Gastrodia elata Bl., and oligosaccharides prepared thereof with anti-pancreatic cancer cell growth activities. Carbohydr Polym. 2011, 86:1300-1305.

　　24.Xu Y, Dong Q, Qiu H, Ma, C-W, Ding K*. A homogalacturonan from radix of Platycodon grandiflorum and the anti-angiogenesis activity of poly-/oligogalacturonic acids derived thereof. Carbohydr Res. 2011, 346(13):1930-6.

　　25.Qiu H, Yang B, Pei ZC, Zhang Z, Ding K*.WSS25 inhibits growth of xenografted hepatocellular cancer cells in nude mice by disrupting angiogenesis via blocking BMP/SMAD/ID1 signaling. J Biol Chem. 2010, 285(42):32638-46.

　　26.Xu Y, Dong Q*, Qiu H, Cong R, Ding K*. Structural characterization of an arabinogalactan from Platycodon grandiflorum roots and anti-angiogenic activity of its sulfated derivative. 2010, Biomacromolecules, 2010, 11(10):2558-66.

　　27.Dong Q, Liu X, Yao J, Dong X, Ma C, Xu Y, Fang J, Ding K*. Structural characterization of a pectic polysaccharide from Nerium indicum flowers. Phytochemistry, 2010, 71:1430–1437.

　　28.Duan J, Chen VL, Dong Q, Ding K*, Fang J. Chemical structure and immunoinhibitory activity of a pectic polysaccharide containing glucuronic acid from the leaves of Diospyros kaki. Int J Biol Macromol. 2010, 46(5):465-70.

　　29.Duan J, Dong Q, Ding K*, Fang J. Characterization of A pectic polysaccharide from the leaves of diospyros kaki and its modulating activity on lymphocyte proliferation. Biopolymers. 2010, 93(7),649-656

　　30.Tong X, Qiu H, Zhang X, Shi L, Wang G, Ji F, Ding H, Tang W*, Ding K* Zuo J*. WSS45, a sulfated α-D-glucan compound, strongly interfere with Dengue 2 virus infection in vitro, Acta Pharmacologica Sinica, 2010, 31(5):585-92

　　31.Wang S, Zhang Z, Lin X, Xu DS, Feng Y*, Ding K*. A Polysaccharides, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. Glycobiology. 2010, 20 (4): 473-484.

　　32.Zhang Z, Wang S, Qiu H, Duan C, Ding K*, Wang Z*. Waltonitone induces human hepatocellular carcinoma cells apoptosis in vitro and in vivo. Cancer Lett, 2009, 286: 223–231.

　　33.Hu K, Liu Q, Wang S, Ding K*. New oligosaccharides prepared by acid hydrolysis of the polysaccharides from Nerium indicum Mill and their anti- angiogenesis activities. Carbohydr. Res., 2009, 344:198–203.