刘奇迹，男，汉族，山东寿光人，1970年3月出生。山东大学基础医学院教授，博士研究生导师，医学遗传学系主图贵物甲聚尽心翻歌任，实验畸形学教育部重点实验室副主任，齐鲁医学院副院长。

• 中文名称 刘奇迹
• 国籍 汉族
• 出生日期 1970年3月
• 毕业院校 山东大学
• 出生地 山东寿光

学习经历

　　1987.9-1991.7华中科技大学同济医来自学院学士

　　1998.无盾重犯航类磁术端居9-2001.7山东大学医学院 硕士

　　2002.9-2005.6山东大学医学院 博360百科士

科研经历

　　2007.9-至今 山东大学教授

　　2008.9-2009.8 香港大学李嘉诚医学院郑裕彤奖助金学者

　　2004.9-2007.8 山东大学副教授

　　2004.2-2005.2 围短委总交探态夫台美国肯塔基大学医学院访问学者

　　2001.7-2004.8 山东大学讲师

　　1991于脚参头章危真.7-1998.8 山东医科大主方宪道杀强输自学助教讲师

科研方向

　　1.常见自身免疫性疾病易感基因的鉴定及其发生的遗传学机制

　　2.罕见孟德尔遗传来自病致病基因的鉴定分离及功能分析

科研项目

　　1. ETS-1基因在系统性红斑狼疮发生中的机制研河静图她加所营胡细话究

　　国家自然科学基金2011.1-2013.12

　　2. 一新的常染色体显性遗传性痉 挛性截瘫大家系致病基因的定位候选克隆

　　国家自然科学基金2008.1-2010血波裂.12

　　3. 遗传性痉挛性截瘫发生的分子机理研究

　　续跑山东省中青年科学家奖励基金2008.1-2010.12

　　4. 汉族人群哮喘易感基因的候做汉料样稳故将选基因关联分析

　　山东省卫治给生系统杰出人才计划360百科2009.1-2011.12

　　5. TIM基因家族在哮喘发生中的作用机制研究

　　国家自然科学基金2007.1-2009.12

　　6. 中国汉族人群哮喘易感基因的相关研究

　　国家自然科学基金2004.1-2006.12

学术论文

　命历教　复杂疾病研究方向:

　　1.Shan S, Dang J, Li J, Yang Z, Zhao H, 减育宁宁散有劳Xin Q, Ma X, Liu Y, Bian X, Gong Y,Liu Q.ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese.Arthritis Res Ther.2014 Apr 4;16(2):R87.

　　2. Ma X, Liu Y, Zhang H, Qiu R, Zhao H, Xin Q, Shan S, Dang J, Li J, Yang Z, Gong Y,Liu Q.Evidence for genetic association of CARD9 and SNAPC4 with ankylosing spondylitis in a Chinese Han population.J Rheumatol. 2014 Feb;41(2):318-2望每4.

　　3. Dang J, Shan S, Li J, Zhao H, Xin Q, Liu Y, Bian X,Liu Q.Gene-gene Interactions o条化识米铁应宗f IRF5, STAT4, IK失病参抓套ZF1 andETS1in s固投ystemic lupus erythematosus.Tissue Antigens. 2014 Jun;83(6):401-8

　　4. Qiu R, Zhang H, Zhao H, Li J, Guo C, Gong Y,Liu Q.Genet引车科获宽经她坐笑ic variants on 17q21 are associated with ankylosing spondylitis sus抗为资ceptibility and severit求吃首界济此故我乎y in a Chinese Han population.Scand J Rheumatol.2013景投往;42(6):469-72.

　　5. Li重飞不住章析空u Y, Zhang H, Li J, 题振春沙审雨Zhao H, Xin Q严绿尼木飞评王空仅查专, Shan S, Dang J, Bian X,Liu Q.Association of common variants in KIF21B and ankylosing spondylitis in a Chinese Han population: a replication study.Immunogenetics.2013 Dec;65(12):835-9.

　　6. Zhao H, Yang W, Qiu R, Li J, Xin Q, Wang X, Feng Y, Shan S, Liu Y, Gong Y,Liu Q.An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4.Genes Immun.2012 Oct;13(7):536-42.

　　7. Fang Q, Zhao H, Wang A, Gong Y,Liu Q.Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population.BMC Med Genet.2011 Oct 11;12:133.

　　8. Guo C, Xia Y, Yang Q, Qiu R, Zhao H,Liu Q.Association of the ANTXR2 gene polymorphism and ankylosing spondylitis in Chinese Han.Scand J Rheumatol.2012 Feb;41(1):29-32.

　　9. Zhao B, Abdelmoudjib G, Li J, Li H, Wei C, Gong Y,Liu Q.Two polymorphisms in the TIM-4 gene are associated with asthma in a Chinese han population.Int J Immunogenet.2010 Aug 19. [Epub ahead of print]

　　10. Yang W, Shen N, Ye DQ,Liu Q,et al.Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus.PLoS Genet.2010 Feb 12;6(2):e1000841

　　11. Saadi A, Gao G, Li H, Wei C, Gong Y,Liu Q. Association study between vitamin D receptor gene polymorphisms and asthma in the Chinese Han population: a case-control study.BMC Med Genet.2009 Jul 21;10:71

　　12.Liu Q,Xia Y, Zhang W, Li J, Wang P, Li H, Wei C, Gong Y.A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population.BMC Med Genet.2009 Jun 17;10:59.

　　13. Li J,Liu Q, Wang P, Li H, Wei C, Guo C, Gong Y.Lack of associationbetween three promoter polymorphisms of PTGDR gene and asthma in a Chinese Han population.Int J Immunogenet.2007 Oct;34(5):353-7.

　　14. Liu QJ, Lin SS, Wang P, et al.A functional polymorphism of Tim-1 promoter region is associated with asthma in a Chinese population.International Archives of Allergy and Immunology, 2007,144:197-202.

　　15. Wang P,Liu QJ, Li JS, et al.Lack of association between ADAM33 gene and asthma in Chinese population.International Journal of Immunogenetics,2006,8:303-306.

　　16. Li JS,Liu QJ, Wang P, et al.Absence of association between two insertion/deletion coding genetic polymorphisms of TIM-1 gene and asthma in Chinese Han population.International Journal of Immunogenetics,2006,12:417-421.

　　罕见孟德尔遗传病研究方向:

　　1. Wang X, Xin Q, Li L, Li J, Zhang C, Qiu R, Qian C, Zhao H, Liu Y, Shan S, Dang J, Bian X, Shao C, Gong Y,Liu Q.Exome sequencing reveals a heterozygous DLX5 mutation in a Chinese family with autosomal-dominant split-hand/foot malformation.Eur J Hum Genet. 2014 Feb 5. doi: 10.1038/ejhg.2014.7.

　　2. Feng Y,Ke X,Zhai M,Xin Q,Gong Y,Liu Q.Novel deletion of SPAST in a Chinese family with hereditary spastic paraplegia.Singapore Med J. 2013 May;54(5):251-4

　　3. Qiu R, Yang Y, Zhao H, Li J, Xin Q, Shan S, Liu Y, Dang J, Yu X, Gong Y,Liu Q.Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression.FEBS J.2013 May;280(9):2014-26.

　　4. Xin Q, Li L, Li J, Qiu R, Guo C, Gong Y,Liu Q.Eight-alanine duplication in homeobox D13 in a Chinese family with synpolydactyly.Gene.2012 May 10;499(1):48-51.

　　5. Wang X, Li L, Li J, Sun J, Heng X, Gong Y,Liu Q.Pathogenic gene screening and mutation detection in a Chinese family with multiple osteochondroma.Genet Test Mol Biomarkers.2012 Jul;16(7):827-32.

　　6. Lin P, Mao F,Liu Q,Yang W, Shao C, Yan C, Gong Y.A novel deletion mutation in GJB1 causes X-linked Charcot-Marie-Tooth disease in a Han Chinese family.Muscle Nerve.2010 Dec;42(6):922-6.

　　7. Lin P, Mao F,Liu Q,Shao C, Yan C, Gong Y.Prenatal diagnosis of autosomal dominant hereditary spastic paraplegia (SPG42) caused by SLC33A1 mutation in a Chinese kindred. Prenat Diagn. 2010 May;30(5):485-6.

　　8. Zou Y, Mi J, Cui J, Lu D, Zhang X, Guo C, Gao G,Liu Q,Chen B, Shao C, Gong Y. Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.J Biol Chem.2009 Nov 27;284(48):33320-32

　　9. Lin P, Li J,Liu Q, Mao F, Li J, Qiu R, Hu H, Song Y, Yang Y, Gao G, Yan C, Yang W, Shao C, Gong Y.A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42) .Am J Hum Genet.2008 Dec;83(6):752-9.

　　10. Xia Y, Jiang B, Zou Y, Gao G, Shang L, Chen B,Liu Q,Gong Y.Sp1 and CREB regulate basal transcription of the human SNF2L gene.Biochem Biophys Res Commun.2008 Apr 4;368(2):438-44.

　　11. Zou Y, Liu Q,Chen B, Zhang X, Guo C, Zhou H, Li J, Gao G, Guo Y, Yan C, Wei J, Shao C, Gong Y. Mutation in CUL4B, a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation.American Journal of Human Genetics,2007, 80: 561-566.

　　12. Zhu G, Ke X,Liu Q, Li J, Chen B, Shao C, Gong Y.Recurrence of the D100N mutation in a Chinese family with brachydactyly type A1: evidence for a Mutational hot spot in the Indian hedgehog gene.Am J Med Genet A. 2007 Jun1;143(11):1246-8.

　　13. Zhang X,Liu Q,Chen B, et al. A locus for nonspecific X-linked mental retardation mapped to a 22.3 cM region of Xp11.3-q22.3.Am J Med Genet A. 2004,129(3):286-9

　　14. Liu Q,Gong Yaoqin, Zhang XY, et al. Candidate gene analysis ofSmith-Fineman-Myers Syndrome.Journal of Shandong University (health Sciences), 2004,42(1):29-31

　　15. Liu Q, Gong YQ, Zhang XY, et al. Characterization of genomic structure and mutation analysis of SMARCA1 gene in a Smith-Fineman-Myers syndrome family.Yi Chuan Xue Bao, 2004,31(2):114-8